| Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles. | |
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MedLine Citation:
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PMID: 19967121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Superparamagnetic beads in giant unilamellar vesicles are used to facilitate magnetic manipulation, positioning, agitation and mixing of ultrasmall liquid volumes. Vesicles act as leakproof picoliter reaction vessels in an aqueous bulk solution and can be deliberately conveyed by an external magnetic field to a designated position. Upon application of an external magnetic field the beads align to form extended chains. In a rotating magnetic field chains break up into smaller fragments caused by the interplay of viscous friction and magnetic attraction. This process obeys a simple relationship and can be exploited to enhance mixing of the vesicle content and the outer solution or adjacent vesicle volumes exactly at the position of release. |
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Authors:
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Thomas Franke; Lothar Schmid; David A Weitz; Achim Wixforth |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-06 |
Journal Detail:
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Title: Lab on a chip Volume: 9 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 2831-5 Citation Subset: IM |
Affiliation:
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University of Augsburg, Experimental Physics 1, Augsburg, Germany. thomas.franke@physik.uni-augsburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Friction Lipids / chemistry* Magnetics* Microfluidic Analytical Techniques / instrumentation, methods* Microspheres Nanoparticles / chemistry Particle Size Surface Properties Unilamellar Liposomes / chemistry* Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Unilamellar Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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