| Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. | |
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MedLine Citation:
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PMID: 10369354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: In subjects with subcortical ischemic vascular dementia (SIVD), tissue vacuolization, myelin pallor, and demyelination have been found on pathologic examination of white matter signal hyperintensities (WMSH). Magnetization transfer ratio (MTR) values provide a potential measure of compromised white matter integrity. The purpose of this study was to determine if there were differences in MTR of WMSH between subjects with SIVD and cognitively normal healthy control subjects. METHODS: Fifteen subjects with SIVD and 16 control subjects of comparable age and sex were studied. MTR images were coregistered to MR images segmented into tissue classes (gray matter, white matter, CSF, WMSH, and lacunar infarcts). MTR of WMSH was compared across groups and examined by WMSH location, size, and total burden. RESULTS: WMSH burden was greater in SIVD patients than in control subjects (2.4% vs 0.67%). MTR of WMSH did not differ between groups, but MTR of periventricular WMSH was lower in SIVD patients than in control subjects (37.6% vs 39.4%). Even after accounting for covariant effects of lesion burden, there was still a trend toward reduced periventricular WMSH MTR in the group with dementia. There was no correlation between WMSH MTR and WMSH lesion size. CONCLUSION: These findings are consistent with observations that pathologic changes in vascular dementia are most severe in the periventricular white matter and suggest that insight into the pathophysiology of SIVD might be gleaned from studies of the periventricular region. |
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Authors:
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J L Tanabe; F Ezekiel; W J Jagust; B R Reed; D Norman; N Schuff; M W Weiner; H Chui; G Fein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 20 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-27 Completed Date: 1999-07-27 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 839-44 Citation Subset: IM |
Affiliation:
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Department of Radiology, New York University Medical Center, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brain / pathology* Brain Ischemia / complications Dementia, Vascular / diagnosis*, etiology, pathology Female Humans Magnetic Resonance Imaging* Male |
| Grant Support | |
ID/Acronym/Agency:
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AG 10129/AG/NIA NIH HHS; DA-05683-02/DA/NIDA NIH HHS; P01 AG012435-06A10002/AG/NIA NIH HHS; P01 AG012435-06A19001/AG/NIA NIH HHS; P01 AG12535/AG/NIA NIH HHS |
| Comments/Corrections | |
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