| Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis. | |
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MedLine Citation:
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PMID: 19435751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load. OBJECTIVE: We investigated if normal-appearing white matter (NAWM) and grey matter tissue changes assessed by magnetization transfer ratio were associated with long-term disability. METHODS: Sixty-nine people were assessed 20 years after presentation with a clinically isolated syndrome (CIS) [28 still CIS, 31 relapsing-remitting multiple sclerosis, 10 secondary progressive multiple sclerosis], along with 19 healthy subjects. Mean magnetization transfer ratio, peak height (PH) and peak location of the normalized magnetization transfer ratio histograms were determined in NAWM and grey matter, as well as, white matter and GM Fraction (GMF) and T(2)-weighted lesion load. RESULTS: Median expanded disability status scale for multiple sclerosis patients was 2.5 (range 1-8). GM-PH, and less so, NAWM mean and peak location, were lower in multiple sclerosis patients (P = 0.009) versus controls, relapsing-remitting multiple sclerosis versus CIS (P = 0.008) and secondary progressive multiple sclerosis versus relapsing-remitting multiple sclerosis (P = 0.002). GM-PH (as well as GMF) correlated with expanded disability status scale (r(s) = -0.49; P = 0.001) and multiple sclerosis functional score (r(s) = 0.51; P = 0.001). GM-PH independently predicted disability with similar strength to the associations of GMF with clinical measures. CONCLUSION: Grey matter damage was related to long-term disability in multiple sclerosis cohort with a relatively low median expanded disability status scale. Markers of intrinsic grey matter damage (magnetization transfer ratio) and tissue loss offer clinically relevant information in multiple sclerosis. |
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Authors:
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L K Fisniku; D R Altmann; M Cercignani; D J Tozer; D T Chard; J S Jackson; K A Miszkiel; K Schmierer; A J Thompson; D H Miller |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-12 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 15 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-08-21 Revised Date: 2011-11-04 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 668-77 Citation Subset: IM |
Affiliation:
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NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK. l.fisniku@ion.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrophy Brain / pathology* Disability Evaluation Female Humans Magnetic Resonance Imaging* Male Middle Aged Multiple Sclerosis, Chronic Progressive / pathology* Multiple Sclerosis, Relapsing-Remitting / pathology* Nerve Fibers, Myelinated / pathology Neurons / pathology Predictive Value of Tests Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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075941//Wellcome Trust; 075941//Wellcome Trust; 748//Multiple Sclerosis Society; //Department of Health |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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