Document Detail


Magnetization transfer for the assessment of bowel fibrosis in patients with Crohn's disease: initial experience.
MedLine Citation:
PMID:  23138635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: To assess the feasibility of magnetization transfer (MT) imaging of the bowel wall in patients with Crohn's disease (CD), and to evaluate its utility for the detection of intestinal fibrosis.
MATERIALS AND METHODS: In this prospective study, 31 patients (age 39.0 ± 13.2 years) with CD were examined in a 1.5T MR scanner. To establish a standard of reference, two independent readers classified the patients in different disease states using standard MR enterography, available clinical data and histological findings. In addition to the standard protocol, a 2D gradient-echo sequence (TR/TE 32 ms/2.17 ms; flip angle 25°) with/without 1,100 Hz off-resonance prepulse was applied. MT ratios (MTR) of the small bowel wall were computed off-line on a pixel-by-pixel basis.
RESULTS: The MT sequences acquired images of sufficient quality and spatial resolution for the evaluation of the small bowel wall without detrimental motion artefacts. In normal bowel wall segments, an intermediate MTR of 25.4 ± 3.4 % was measured. The MTR was significantly increased in bowel wall segments with fibrotic scarring (35.3 ± 4.0 %, p < 0.0001). In segments with acute inflammation, the mean MTR was slightly smaller (22.9 ± 2.2 %).
CONCLUSION: MT imaging of the small bowel wall is feasible in humans with sufficient image quality and may help with the identification of fibrotic scarring in patients with CD.
Authors:
Shila Pazahr; Iris Blume; Pascal Frei; Natalie Chuck; Daniel Nanz; Gerhard Rogler; Michael Patak; Andreas Boss
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Publication Detail:
Type:  Journal Article     Date:  2012-11-09
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  26     ISSN:  1352-8661     ISO Abbreviation:  MAGMA     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-31     Completed Date:  2014-01-08     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  291-301     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Algorithms*
Crohn Disease / pathology*
Female
Fibrosis
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Intestines / pathology*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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