Document Detail


Magnetite nanoparticles doped photoresist derived carbon as a suitable substratum for nerve cell culture.
MedLine Citation:
PMID:  23010126     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A method which alters the substrate's physical and electrochemical properties by doping photoresist derived carbon with magnetite nanoparticles has been developed to enhance the existing substrate's ability to foster cell growth. Cyclic voltammetry, scanning electron microscopy and atomic force microscopy are used to evaluate the characters of the prepared film. And then, the magnetite nanoparticles doped carbon film is used as substrate for the growth of nerve cell. Here, rat pheochromocytoma cells are used for culture to test substrate-cell interactions. The results showed an increase in cell concentration and average neurite length with the increase of nanoparticle concentration on the surface. Importantly, the nerve cells can be grown on the magnetite nanoparticles doped carbon even in the absence of nerve growth factor. This finding will potentially provide a new material for nerve regeneration.
Authors:
Zanzan Zhu; Olijora Rezhdo; Matthew Perrone; Zhengzheng Bao; Ahsan Munir; Jianlong Wang; H Susan Zhou; Jiahui Shao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  102C     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  428-434     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, United States.
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