| Magnetite nanocrystal clusters with ultra-high sensitivity in magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 22095763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic iron oxide particles are widely used as contrast agents to improve the sensitivity of magnetic resonance imaging (MRI). Their efficiency in MRI is usually quantified by transverse relaxivity (r(2)) in solution. Herein, we synthesized a series of magnetite nanocrystal clusters (MNCs) with ultra-high transverse relaxivity by a polyol process and studied the relationship between r(2) and size of the MNCs. The sizes of MNCs can be tuned over a wide range from 13 to 179 nm. The r(2) of MNC suspensions as a function of the size of the cluster was analyzed and compared with a theoretical model. We found that MNCs of 64 nm had an r(2) value of 650 mM(-1) s(-1), which was more than three times that of the commercial contrast agent and was among the highest reported for iron oxide materials. Compared with the theoretical model, the r(2) value of the MNC suspension is approximately 0.93 of the theoretical prediction. Imaging of the MNC suspensions was performed in a clinical 1.5 T MRI instrument and a comparison was made between MNCs and commercial contrast agents. MRI indicated that the decrease of signal intensity induced by MNCs was in proportion to the r(2) value, which was in accordance with theoretical predictions. These results demonstrate that MNCs with ultra-high transverse relaxivity and tunable size are promising candidates for molecular imaging and clinical diagnosis in MRI. |
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Authors:
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Fangjie Xu; Changming Cheng; Du-Xing Chen; Hongchen Gu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-11-16 |
Journal Detail:
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Title: Chemphyschem : a European journal of chemical physics and physical chemistry Volume: 13 ISSN: 1439-7641 ISO Abbreviation: Chemphyschem Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: 2012-04-23 Revised Date: 2012-05-22 |
Medline Journal Info:
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Nlm Unique ID: 100954211 Medline TA: Chemphyschem Country: Germany |
Other Details:
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Languages: eng Pagination: 336-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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School of Biomedical Engineering and Med-X Research Institute, Huashan Road Shanghai Jiaotong University, 200030, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ferric Compounds
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chemistry Magnetic Resonance Imaging* Magnetite Nanoparticles / chemistry* Models, Theoretical Polymers / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 0/Magnetite Nanoparticles; 0/Polymers; 0/polyol; 1309-37-1/ferric oxide |
| Comments/Corrections | |
Erratum In:
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Chemphyschem. 2012 Apr 23;13(6):1377 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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