Document Detail

Magnetically targeted delivery of therapeutic agents to injured blood vessels for prevention of in-stent restenosis.
MedLine Citation:
PMID:  22891107     Owner:  NLM     Status:  MEDLINE    
Magnetic guidance is a physical targeting strategy with the potential to improve the safety and efficacy of a variety of therapeutic agents--including small-molecule pharmaceuticals, proteins, gene vectors, and cells--by enabling their site-specific delivery. The application of magnetic targeting for in-stent restenosis can address the need for safer and more efficient treatment strategies. However, its translation to humans may not be possible without revising the traditional magnetic targeting scheme, which is limited by its inability to selectively guide therapeutic agents to deep localized targets. An alternative two-source strategy can be realized through the use of uniform, deep-penetrating magnetic fields in conjunction with vascular stents included as part of the magnetic setup and the platform for targeted delivery to injured arteries. Studies showing the feasibility of this novel targeting strategy in in-stent restenosis models and considerations in the design of carrier formulations for magnetically guided antirestenotic therapy are discussed in this review.
Michael Chorny; Ilia Fishbein; Richard F Adamo; Scott P Forbes; Zoë Folchman-Wagner; Ivan S Alferiev
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Methodist DeBakey cardiovascular journal     Volume:  8     ISSN:  1947-6108     ISO Abbreviation:  Methodist Debakey Cardiovasc J     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-27     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101508600     Medline TA:  Methodist Debakey Cardiovasc J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Division of Cardiology Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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MeSH Terms
Angioplasty / adverse effects,  instrumentation*
Arterial Occlusive Diseases / drug therapy,  therapy*
Cardiovascular Agents / administration & dosage*
Constriction, Pathologic
Coronary Restenosis / drug therapy,  therapy*
Drug Delivery Systems / methods*
Prosthesis Design
Grant Support
Reg. No./Substance:
0/Cardiovascular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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