| Magnetic resonance techniques to monitor the long term evolution of multiple sclerosis pathology and to monitor definitive clinical trials. | |
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MedLine Citation:
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PMID: 9647285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies. |
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Authors:
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D W Paty; H McFarland |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 64 Suppl 1 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-22 Completed Date: 1998-07-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S47-51 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vancouver General Hospital, and the University of British Columbia, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Axons
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pathology Brain / pathology* Clinical Trials as Topic / standards* Demyelinating Diseases / pathology Disease Progression Humans Magnetic Resonance Imaging / methods* Multiple Sclerosis / pathology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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