| Magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 16148633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance spectroscopy (MRS) complements magnetic resonance imaging (MRI) as a non-invasive means for the characterization of tissue. While MRI uses the signal from hydrogen protons to form anatomic images, proton MRS uses this information to determine the concentration of brain metabolites such as N-acetyl aspartate (NAA), choline (Cho), creatine (Cr) and lactate in the tissue examined. The most widely used clinical application of MRS has been in the evaluation of central nervous system disorders.MRS has its limitations and is not always specific but, with good technique and in combination with clinical information and conventional MRI, can be very helpful in diagnosing certain entities. For example, a specific pattern of metabolites can be seen in disorders such as Canavan's disease, creatine deficiency, and untreated bacterial brain abscess. MRS may also be helpful in the differentiation of high grade from low grade brain tumors, and perhaps in separating recurrent brain neoplasm from radiation injury. |
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Authors:
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Sachin K Gujar; Sharad Maheshwari; Isabella Björkman-Burtscher; Pia C Sundgren |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 25 ISSN: 1070-8022 ISO Abbreviation: J Neuroophthalmol Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-08 Completed Date: 2005-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 217-26 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109, USA, and Department of Imaging, Jaslok Hospital and Medical Research Center, 15, Dr. G. Deshmukh road, Mumbai 400026, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspartic Acid
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analogs & derivatives,
metabolism Brain / metabolism Central Nervous System Diseases / diagnosis, metabolism Choline / metabolism Creatine / metabolism Humans Lactic Acid / metabolism Magnetic Resonance Spectroscopy* |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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