| Magnetic resonance spectroscopy in patients with Fabry and Gaucher disease. | |
| | |
MedLine Citation:
|
PMID: 20227208 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Fabry and Gaucher diseases are rare progressive inherited disorders of glycosphingolipid metabolism that affect multiple organ systems. The aim of this study was to investigate evidence for metabolic changes in the central nervous system involvement using proton magnetic resonance spectroscopic imaging. METHODS: Seven Fabry and eight Gaucher patients were included into this study. A two-dimensional, spectroscopic imaging method with an ultra-short echo-time of 11ms was used at a 3T whole body magnet. Absolute metabolic values were retrieved using internal water scaling. Results were compared, with sex- and age-matched controls. RESULTS: In contrast to previous findings, absolute and relative metabolite values of N-acetyl-aspartate (NAA) or NAA/Creatine (Cr), Cr, Choline (Cho) or Cho/Cr and myo-Inositol (mI) or mI/Cr revealed no, differences between Fabry and Gaucher Type 1 (GD1) patients and controls. Average values were, 10.22, 6.32, 2.15 and 5.39mMol/kg wet weight for NAA, Cr, Cho and mI, respectively. In this study, we found significantly decreasing NAA/Cho with increasing age in all three groups (Fabry, GD1, patients and healthy controls) (between 5 and 8% per decade). CONCLUSIONS: There were no changes of the quantified metabolites detected by MRS in normal appearing white matter. This study shows the importance of sex- and age-matched controls. |
| | |
Authors:
|
S Gruber; W Bogner; A Stadlbauer; M Krssak; O Bodamer |
Related Documents
:
|
11415908 - Quantitative proton mr spectroscopic imaging in acute disseminated encephalomyelitis. 10758988 - American college of cardiology/european society of cardiolgoy international study of an... 15485008 - Magnetic resonance imaging and proton magnetic resonance spectroscopy in neuro-behçet'... 15503328 - Quantitative proton mr spectroscopic imaging of the mesial temporal lobe. 8668808 - Anterosuperior labral variants of the shoulder: appearance on gradient-recalled-echo an... 21573228 - Mapping traumatic axonal injury using diffusion tensor imaging: correlations with funct... |
Publication Detail:
|
Type: Journal Article Date: 2010-03-12 |
Journal Detail:
|
Title: European journal of radiology Volume: 79 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-08-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 295-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Department of Radiology, MR-Centre of Excellence, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Crime scene investigation (as seen on TV).
Next Document: Tumorsize dependent detection rate of endorectal MRI of prostate cancer-A histopathologic correlatio...