Document Detail

Magnetic resonance spectroscopy in the evaluation of neurotoxicity following cranial irradiation for childhood cancer.
MedLine Citation:
PMID:  10844868     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the role of proton MR spectroscopy (1H-MRS) in the diagnosis and assessment of long-term radiation-related neurotoxicity, 14 children who had received cranial irradiation for the treatment of childhood leukaemia (n = 6) or brain tumours (n = 8) underwent 1H-MRS, MRI and neuropsychological assessment. Short-term effects at 2 months following treatment were studied in a further three patients. MRI abnormalities were observed in nine patients. No statistically significant differences between patients and controls (n = 17) were seen in any of the calculated 1H-MRS metabolite ratios, in any of the three patient groups. On multivariate logistic regression analysis there was a correlation between the choline/water ratio and a low IQ. It is concluded that any systematic radiation-induced changes in the 1H MRS metabolites must be below the detection threshold of this study.
A Davidson; D M Tait; G S Payne; J W Hopewell; M O Leach; M Watson; A D MacVicar; J A Britton; S Ashley
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of radiology     Volume:  73     ISSN:  0007-1285     ISO Abbreviation:  Br J Radiol     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-14     Completed Date:  2000-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  AIM; IM    
Royal Marsden NHS Trust, Sutton, Surrey, UK.
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MeSH Terms
Brain / pathology
Brain Diseases / diagnosis*
Brain Neoplasms / radiotherapy
Child, Preschool
Follow-Up Studies
Leukemic Infiltration / radiotherapy
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuropsychological Tests
Radiation Injuries / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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