| Magnetic resonance spectroscopy in the evaluation of neurotoxicity following cranial irradiation for childhood cancer. | |
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MedLine Citation:
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PMID: 10844868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the role of proton MR spectroscopy (1H-MRS) in the diagnosis and assessment of long-term radiation-related neurotoxicity, 14 children who had received cranial irradiation for the treatment of childhood leukaemia (n = 6) or brain tumours (n = 8) underwent 1H-MRS, MRI and neuropsychological assessment. Short-term effects at 2 months following treatment were studied in a further three patients. MRI abnormalities were observed in nine patients. No statistically significant differences between patients and controls (n = 17) were seen in any of the calculated 1H-MRS metabolite ratios, in any of the three patient groups. On multivariate logistic regression analysis there was a correlation between the choline/water ratio and a low IQ. It is concluded that any systematic radiation-induced changes in the 1H MRS metabolites must be below the detection threshold of this study. |
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Authors:
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A Davidson; D M Tait; G S Payne; J W Hopewell; M O Leach; M Watson; A D MacVicar; J A Britton; S Ashley |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of radiology Volume: 73 ISSN: 0007-1285 ISO Abbreviation: Br J Radiol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-14 Completed Date: 2000-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 421-4 Citation Subset: AIM; IM |
Affiliation:
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Royal Marsden NHS Trust, Sutton, Surrey, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / pathology Brain Diseases / diagnosis* Brain Neoplasms / radiotherapy Child Child, Preschool Follow-Up Studies Humans Infant Leukemic Infiltration / radiotherapy Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Neuropsychological Tests Radiation Injuries / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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