| Magnetic resonance perfusion and permeability imaging in brain tumors. | |
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MedLine Citation:
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PMID: 19959004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence suggests that vascular permeability and the presence of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) are important mediators of brain tumor growth in addition to angiogenesis. Perfusion and permeability magnetic resonance (MR) imaging can now measure parameters such as cerebral blood volume and vascular permeability, which can be directly correlated with these histopathologic changes as well as molecular markers such as VEGF. The major techniques currently used in both the clinical and research settings are T1-weighted steady-state dynamic contrast-enhanced MR imaging (DCE MR imaging) and T2 *-weighted first-pass, dynamic susceptibility contrast MR imaging (DSC MR imaging). The advantages and disadvantages of each technique with regard to characterizing tumor biology are discussed in this article. Most clinicians and investigators are currently using the DSC MR imaging T2 *-weighted technique for brain tumor perfusion MR imaging. The existence of multiple approaches to pathologic classification of human glioma implies that there is a lack of consensus among experts as to which is the single best approach. These multiple grading systems do, however, agree on the histologic parameters that are important in the determination of glioma biology, namely hypercellularity, pleomorphism, vascular endothelial proliferation, mitotic activity, and necrosis. |
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Authors:
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Saulo Lacerda; Meng Law |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroimaging clinics of North America Volume: 19 ISSN: 1557-9867 ISO Abbreviation: Neuroimaging Clin. N. Am. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-04 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211377 Medline TA: Neuroimaging Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 527-57 Citation Subset: IM |
Affiliation:
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Department of Radiology, Mount Sinai Medical Center, New York, NY 10029, USA. saulolacerda@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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diagnosis* Diffusion Magnetic Resonance Imaging / trends* Humans Magnetic Resonance Angiography / trends* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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