| Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease. | |
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MedLine Citation:
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PMID: 21559028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) of the brain could be a powerful tool for discovering early biomarkers in clinically presymptomatic carriers of the Huntington's disease gene mutation (preHD). The aim of this study was to investigate the sensitivity of resting-state perfusion MRI in preHD and to identify neural changes, which could serve as biomarkers for future clinical trials. Differences in regional cerebral blood flow (rCBF) in 18 preHD and 18 controls were assessed with a novel MRI method based on perfusion images obtained with continuous arterial spin labeling. High-resolution structural data were collected to test for changes of brain volume. Compared with controls, preHD individuals showed decreased rCBF in medial and lateral prefrontal regions and increased rCBF in the precuneus. PreHD near to symptom onset additionally showed decreased rCBF in the putamen and increased rCBF in the hippocampus. Network analyses revealed an abnormal lateral prefrontal pattern in preHD far and near to motor onset. These data suggest early changes of frontostriatal baseline perfusion in preHD independent of substantial reductions of gray matter volume. This study also shows the feasibility of detecting neural changes in preHD with a robust MRI technique that would be suitable for longitudinal multisite application. |
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Authors:
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Robert C Wolf; Georg Grön; Fabio Sambataro; Nenad Vasic; Nadine D Wolf; Philipp A Thomann; Carsten Saft; G Bernhard Landwehrmeyer; Michael Orth |
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Publication Detail:
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Type: Journal Article Date: 2011-05-11 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2011-10-27 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1908-18 Citation Subset: IM |
Affiliation:
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Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany. christian.wolf@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / blood supply*, pathology, physiopathology* Cerebrovascular Circulation* Female Humans Huntington Disease / diagnosis*, pathology, physiopathology* Magnetic Resonance Angiography / methods* Male Middle Aged Neurons / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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