| Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. | |
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MedLine Citation:
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PMID: 15770136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: During biliary cirrhosis in rats, organic anion-transporting peptides (Oatps) and ATP-dependent multidrug resistance-associated protein 2 (Mrp2) that are likely to transport the contrast agent Gd-BOPTA through hepatocytes are down-regulated. However, the consequences of such down-regulation on the signal intensity (SI) enhancement are unknown. Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers. MATERIALS AND METHODS: The hepatic SI enhancement during Gd-BOPTA perfusion was measured in livers isolated from normal rats and rats that had a bile duct ligation (BDL) 15, 30, and 60 days before the perfusion. Hepatic injury and transporter expression were measured in control and cirrhotic rats. RESULTS: BDL induced a severe hepatic injury that increased over time with a down-regulation of the transporter expression. The extracellular space (assessed by Gd-DTPA perfusion) increased with the severity of the disease. Gd-BOPTA-induced SI enhancement remained similar in BDL-15 and BDL-30 rats than in control rats but significantly decreased in severe cirrhosis (BDL-60 rats). In comparison, the Mn-DPDP-induced SI enhancement decreases proportionally to the severity of the disease. CONCLUSION: During biliary cirrhosis, Gd-BOPTA-induced SI enhancement could not be related to the hepatic expression of transporters. |
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Authors:
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Corinne Planchamp; Xavier Montet; Jean-Louis Frossard; Rafael Quadri; Bruno Stieger; Peter J Meier; Marko K Ivancevic; Jean-Paul Vallée; François Terrier; Catherine M Pastor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 40 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-16 Completed Date: 2005-06-21 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 187-94 Citation Subset: IM |
Affiliation:
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Département de Radiologie and Division de Gastroentérologie, Höpitaux Universitaires de Genève, Geneva, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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analysis Albumins / analysis Animals Bile Ducts / physiology Blotting, Western Contrast Media* Keratins / analysis Liver Cirrhosis, Experimental / diagnosis* Magnetic Resonance Imaging Meglumine / analogs & derivatives*, diagnostic use* Organic Anion Transporters / analysis Organometallic Compounds / diagnostic use* Perfusion Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Abcc2 protein, rat; 0/Albumins; 0/Contrast Media; 0/Organic Anion Transporters; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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