| Magnetic resonance imaging versus endoscopic ultrasonography for the detection of pancreatic tumours in multiple endocrine neoplasia type 1. | |
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MedLine Citation:
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PMID: 22078814 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: In multiple endocrine neoplasia type 1, the main risk factor for metastases is pancreatic tumour size. We and others recommend limiting surgery to non-functioning pancreatic tumors ≥20mm or growing, based on their size measured with endoscopic ultrasonography. Because endoscopic ultrasonography is invasive, we compared endoscopic ultrasonography (EUS) to non-invasive magnetic resonance imaging (MRI) for the detection of pancreatic tumours ≥10mm in multiple endocrine neoplasia type 1 patients. METHODS: A prospective study was performed in nine participating centres; 90 patients with multiple endocrine neoplasia type 1 underwent EUS and MRI with gadolinium infusion. Gastroenterologists and radiologists were blinded to the results, magnetic resonance images were reviewed centrally. RESULTS: EUS detected 86 tumours ≥10mm, and 48 (53.3%) patients had at least one tumour ≥10mm. MRI detected 67 tumours ≥10mm, and 46 (51.1%) patients had at least one tumour ≥10mm. EUS and MRI agreement was moderate for detection of tumours ≥10mm (Kappa coefficient=0.49), and for selection of patients with tumours ≥10mm (Kappa coefficient=0.55). EUS and MRI missed 11/24 and 4/24 lesions ≥20mm, respectively. EUS failed to identify 9/57 (15.7%) patients with pancreatic tumours ≥10mm, and MRI failed to identify 11/57 (19.3%) patients with pancreatic tumours ≥10mm. CONCLUSIONS: EUS and MRI are complementary and should be performed at initial evaluation in multiple endocrine neoplasia type 1 patients. Whether follow-up should be based on either technique or both, requires further evaluation. |
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Authors:
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Coralie Barbe; Arnaud Murat; Benoit Dupas; Philippe Ruszniewski; Antoine Tabarin; Marie-Pierre Vullierme; Alfred Penfornis; Vincent Rohmer; Eric Baudin; Marc Le Rhun; Delphine Gaye; Claude Marcus; Guillaume Cadiot; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: - ISSN: 1878-3562 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Clinical Research Coordination Unit, Robert Debré Hospital, University Hospital of Reims, Reims, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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