| Magnetic resonance imaging of tablet dissolution. | |
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MedLine Citation:
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PMID: 19602436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) is the technique of choice for measuring hydration, and its effects, during dissolution of tablets since it non-invasively maps (1)H nuclei associated with 'mobile' water. Although most studies have used MRI systems with high-field superconducting magnets, low-field laboratory-based instruments based on permanent magnet technology are being developed that provide key data for the formulation scientist. Incorporation of dissolution hardware, in particular the United States Pharmacopeia (USP) apparatus 4 flow-through cell, allows measurements under controlled conditions for comparison against other dissolution methods. Furthermore, simultaneous image acquisition and measurement of drug concentration allow direct comparison of the drug release throughout the hydration process. The combination of low-field MRI with USP-4 apparatus provides another tool to aid tablet formulation. |
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Authors:
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Kevin P Nott |
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Publication Detail:
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Type: Journal Article Date: 2009-07-12 |
Journal Detail:
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Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft f?r Pharmazeutische Verfahrenstechnik e.V Volume: 74 ISSN: 1873-3441 ISO Abbreviation: Eur J Pharm Biopharm Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109778 Medline TA: Eur J Pharm Biopharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Oxford Instruments Magnetic Resonance, Oxon, United Kingdom. kevin.nott@oxinst.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Diffusion Excipients / chemistry Kinetics Magnetic Resonance Imaging / methods* Pharmaceutical Preparations / chemistry Solubility Tablets / chemistry* Technology, Pharmaceutical / instrumentation, methods Water / analysis |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Pharmaceutical Preparations; 0/Tablets; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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