Document Detail

Magnetic resonance imaging study of the rat cerebral ventricular system utilizing intracerebrally administered contrast agents.
MedLine Citation:
PMID:  1943681     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance imaging (MRI) was employed to study the rat brain in conjunction with intracerebral (ic) injection of three contrast agents: GdHAM, GdDPTA, and MnCl2. The results demonstrate several advantages of ic administration of MRI contrast agents over the other routes of injection in examining CSF dynamics and brain ventricular structure. Apparent affinity of the luminal ventricular wall of the brain for positively charged GdHAM and Mn2+ ions is observed, presumably reflecting the presence of negatively charged wall components. Respiratory distress caused by (intravenous) injection of GdHAM was found to be minimized in the case of ic injections. Time-dependent changes in observed contrast indicate that diffusive processes rather than flow of CSF play a dominant role in distributing the contrast agents. Possible applications of this approach in brain research are discussed.
X M Wan; T C Fu; P H Smith; J R Brainard; R E London
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  21     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-06     Completed Date:  1991-12-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
Laboratory of Molecular Biophysics, NIEHS, NIH, Research Triangle Park, North Carolina 27709.
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MeSH Terms
Cerebral Ventricles / anatomy & histology*
Contrast Media
Gadolinium / diagnostic use
Gadolinium DTPA
Injections, Intraventricular
Magnetic Resonance Imaging*
Manganese / diagnostic use
Manganese Compounds*
Organometallic Compounds / diagnostic use
Pentetic Acid / diagnostic use
Rats, Inbred Strains
Reg. No./Substance:
0/Chlorides; 0/Contrast Media; 0/Manganese Compounds; 0/Organometallic Compounds; 67-43-6/Pentetic Acid; 7439-96-5/Manganese; 7440-54-2/Gadolinium; 7773-01-5/manganese chloride; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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