| Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats. | |
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MedLine Citation:
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PMID: 20485295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamic and cerebrovascular factors are crucially involved in secondary damage after traumatic brain injury (TBI). With magnetic resonance imaging, this study aimed to quantify regional cerebral blood flow (CBF) by arterial spin labeling and cerebral blood volume by using an intravascular contrast agent, during 14 days after lateral fluid-percussion injury (LFPI) in rats. Immunohistochemical analysis of vessel density was used to evaluate the contribution of vascular damage. Results show widespread ipsilateral and contralateral hypoperfusion, including both the cortex and the hippocampus bilaterally, as well as the ipsilateral thalamus. Hemodynamic unrest may partly be explained by an increase in blood vessel density over a period of 2 weeks in the ipsilateral hippocampus and perilesional cortex. Furthermore, three phases of perilesional alterations in CBF, progressing from hypoperfusion to normal and back to hypoperfusion within 2 weeks were shown for the first time in a rat TBI model. These three phases were similar to hemodynamic fluctuations reported in TBI patients. This makes it feasible to use LFPI in rats to study mechanisms behind hemodynamic changes and to explore novel therapeutic approaches for secondary brain damage after TBI. |
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Authors:
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Nick Mark Edward Alexander Hayward; Pasi I Tuunanen; Riikka Immonen; Xavier Ekolle Ndode-Ekane; Asla Pitkänen; Olli Gröhn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-19 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-02-03 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 166-77 Citation Subset: IM |
Affiliation:
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Biomedical Imaging Unit, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Blood Vessels / pathology Blood Volume / physiology Brain Injuries / mortality, pathology, physiopathology* Cerebrovascular Circulation / physiology* Functional Laterality / physiology Hemodynamics / physiology* Hydrogen-Ion Concentration Image Processing, Computer-Assisted Immunohistochemistry Magnetic Resonance Imaging Male Rats Rats, Sprague-Dawley Tissue Fixation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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