Document Detail

Magnetic resonance imaging regional T1 abnormalities at term accurately predict motor outcome in preterm infants.
MedLine Citation:
PMID:  17606537     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to assess whether periventricular leukomalacia findings are sufficiently sensitive for predicting the severity of motor prognosis by conventional MRI in the near term. METHODS: Preterm infants with T1 hyperintensity or cysts in the periventricular regions on term MRI were selected, and their gross motor functions were evaluated at the age of 3 to 5 years. Sixty-two infants had findings of T1 hyperintensity or cysts, and except for infants with these findings, none were diagnosed later as periventricular leukomalacia. RESULTS: All 37 patients with cerebral palsy had periventricular lesions with T1 hyperintensity or cysts in the corona radiata above the posterior limb of the internal capsule on coronal sections. Small T1 hyperintensity lesions were seen on coronal slices and were often difficult to detect on axial slices. All of the 17 infants with T1 hyperintensity findings sparing the corona radiata above the posterior limb of the internal capsule showed normal motor development, irrespective of findings of ventriculomegaly. There was a tendency for the presence of widespread lesions in corona radiata above the posterior limb of the internal capsule to be correlated with the severity of motor handicap. CONCLUSIONS: Lesions in the corona radiata above the posterior limb of the internal capsule on a coronal view by term MRI were useful for predicting motor prognosis in preterm infants with periventricular leukomalacia.
Yukiko Nanba; Kiyoshi Matsui; Noriko Aida; Yoshiaki Sato; Katsuaki Toyoshima; Motoyoshi Kawataki; Rikuo Hoshino; Makiko Ohyama; Yasufumi Itani; Akiko Goto; Akira Oka
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Publication Detail:
Type:  Journal Article     Date:  2007-06-04
Journal Detail:
Title:  Pediatrics     Volume:  120     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e10-9     Citation Subset:  AIM; IM    
Department of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
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MeSH Terms
Brain / pathology*
Cerebral Palsy / complications,  diagnosis*
Child, Preschool
Cysts / diagnosis
Infant, Newborn
Infant, Premature*
Internal Capsule / pathology
Leukomalacia, Periventricular / complications,  diagnosis*
Magnetic Resonance Imaging*
Motor Skills Disorders / diagnosis,  etiology
Neurologic Examination
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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