Document Detail

Magnetic resonance imaging of obliterated arteriovenous malformations up to 23 years after radiosurgery.
MedLine Citation:
PMID:  9120620     Owner:  NLM     Status:  MEDLINE    
The authors report outcomes in 18 patients with arteriovenous malformations (AVMs) who were treated with gamma knife radiosurgery and in whom magnetic resonance (MR) imaging was obtained a mean of 14 years (range 8-23 years) after treatment and 10 years (range 4-17 years) after confirmed obliteration of the AVM. All patients were asymptomatic after radiosurgery and during the time of the study. In five patients (28%), cyst formation was observed that corresponded to the site of the obliterated AVM. Cyst formation and contrast enhancement on MR imaging could not be statistically correlated to the radiation dose. In 11 (61%) of the 18 patients, contrast enhancement that was not related to a recanalization of the nidus was observed in the target area. In three patients (17%), an increased T2-weighted signal was detected at the site of previous AVM; this was interpreted as gliosis or demyelination, which appeared to be dose dependent. The study illustrates that cyst formation, contrast enhancement, and an increased T2-weighted signal can be observed in asymptomatic patients in the area that was targeted for AVM radiosurgery up to 23 years after the procedure. The report provides new and essential information about long-term effects on normal tissue after radiosurgery and provides a basis for the interpretation of MR studies in the follow up of small AVMs treated by radiosurgery.
L Kihlström; W Y Guo; B Karlsson; C Lindquist; M Lindqvist
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  86     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-23     Completed Date:  1997-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  589-93     Citation Subset:  AIM; IM    
Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Brain / pathology
Follow-Up Studies
Intracranial Arteriovenous Malformations / diagnosis*,  surgery*
Magnetic Resonance Imaging*
Middle Aged
Time Factors
Comment In:
J Neurosurg. 1997 Dec;87(6):979-80   [PMID:  9384417 ]

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