| Magnetic resonance imaging of the neonatal piglet brain. | |
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MedLine Citation:
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PMID: 22258129 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction:Appeal for the domestic pig as a preclinical model for neurodevelopmental research is increasing. One limitation, however, is lack of magnetic resonance imaging (MRI) methods for brain volume quantification in the neonatal piglet. The purpose of this study was to develop and validate MRI methods for estimating brain volume in piglets.Results:The results showed that MRI and manual segmentation reliably estimated the changes in volume of different brain regions in 2- and 5-wk-old piglets. Substantial increases in the volumes of all brain regions examined were evident during the 3-wk period.Discussion:MRI can provide accurate estimates of brain region volume during the neonatal period in piglets. A piglet model that can be used in longitudinal studies may be useful for investigating how experimental (e.g., nutrition, infection) factors affect brain growth and development.Methods:Anatomic MRI data (non-longitudinal) were acquired 2- and 5-wk-old piglets using a three--dimensional T1-weighted magnetization-prepared gradient echo (MPRAGE) sequence on a MAGNETOM Trio 3T imager. Manual segmentation was performed for volume estimates of total brain, cortical, diencephalon, brainstem, cerebellar, and -hippocampal regions. The MRI-based hippocampal volume estimates in 2- and 5-wk-old piglets were validated using histological techniques and the Cavalieri method. |
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Authors:
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Matthew S Conrad; Ryan N Dilger; Alec Nickolls; Rodney W Johnson |
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Publication Detail:
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Type: Journal Article Date: 2011-12-21 |
Journal Detail:
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Title: Pediatric research Volume: 71 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Affiliation:
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Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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