| Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. | |
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MedLine Citation:
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PMID: 18922631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to analyse (i) the metastatic behaviour of human melanoma FEMX-1 cells in scid mice after surgical excision of the PT and (ii) to evaluate the feasibility of magnetic resonance imaging (MRI) for the detection of melanoma metastases. Histology proved both high specificity (95%), and high sensitivity of MRI detection of melanoma metastasis. CEACAM1, L1, and HPA-binding site expression, all markers predicting metastasis in clinical studies, were preserved in the metastatic nodules. Thus, our xenograft model closely resembles the clinical situation of post-operative development of distant organ metastasis and demonstrates that MRI is a sensitive and highly qualified technology for intra-vital monitoring of melanoma progression. |
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Authors:
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Anka Thies; Kersten Peldschus; Harald Ittrich; Gerhard Adam; Peter Altevogt; Christoph Wagener; Udo Schumacher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-14 |
Journal Detail:
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Title: Cancer letters Volume: 274 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-16 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 194-200 Citation Subset: IM |
Affiliation:
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Zentrum für Experimentelle Medizin, Institut für Anatomie II: Experimentelle Morphologie, Universitätsklinikum Hamburg Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. thies@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Humans Immunohistochemistry Melanoma / diagnosis*, pathology Mice Mice, SCID Neoplasm Metastasis Transplantation, Heterologous Tumor Markers, Biological |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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