Document Detail

Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis.
MedLine Citation:
PMID:  8360329     Owner:  NLM     Status:  MEDLINE    
Recent advances in fast magnetic resonance imaging (MRI) techniques have allowed quantification of parameters such as T1 relaxation time, which can be modified by changes in the water content of a tissue. We have used this new method to study the evolution of blood-brain barrier (BBB) changes after adoptive transfer of MBP-specific (AT-EAE) and ovalbumin-specific T cell lines in Lewis rats. Measurable changes in T1 relaxation time suggesting widespread increase in BBB permeability were found, starting on day 3 post inoculation (p.i.), in the midbrain and brainstem of AT-EAE rats. In addition, we noted a significant decrease in T1 relaxation time before injection of a paramagnetic agent, in the cisternal cerebrospinal fluid (CSF) of diseased animals, starting on day 5 p.i. In vitro measurement of T1 in CSF containing various concentrations of albumin, IgM and glucose showed that, at physiological concentrations, a T1 decrease is mainly associated with an increase in albumin concentration. A moderate increase in BBB and blood-CSF barrier permeability was found as early as 4-8 h p.i., in rats injected with MBP-specific as in animals injected with ovalbumin-specific T cell lines, suggesting a non-specific mechanism. Experimental MRI may become a powerful tool to sequentially analyse changes in barrier dynamics, for example following pharmacological intervention.
P A Seeldrayers; J Syha; S P Morrissey; H Stodal; K Vass; S Jung; T Gneiting; H Lassmann; A Haase; H P Hartung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  46     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Neurologische Klinik, Julius-Maximilians-Universität Würzburg, Germany.
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MeSH Terms
Blood-Brain Barrier*
Brain / pathology
Encephalomyelitis, Autoimmune, Experimental / cerebrospinal fluid,  immunology,  pathology*
Immunization, Passive
Magnetic Resonance Imaging
Rats, Inbred Lew
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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