| Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis. | |
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MedLine Citation:
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PMID: 8360329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances in fast magnetic resonance imaging (MRI) techniques have allowed quantification of parameters such as T1 relaxation time, which can be modified by changes in the water content of a tissue. We have used this new method to study the evolution of blood-brain barrier (BBB) changes after adoptive transfer of MBP-specific (AT-EAE) and ovalbumin-specific T cell lines in Lewis rats. Measurable changes in T1 relaxation time suggesting widespread increase in BBB permeability were found, starting on day 3 post inoculation (p.i.), in the midbrain and brainstem of AT-EAE rats. In addition, we noted a significant decrease in T1 relaxation time before injection of a paramagnetic agent, in the cisternal cerebrospinal fluid (CSF) of diseased animals, starting on day 5 p.i. In vitro measurement of T1 in CSF containing various concentrations of albumin, IgM and glucose showed that, at physiological concentrations, a T1 decrease is mainly associated with an increase in albumin concentration. A moderate increase in BBB and blood-CSF barrier permeability was found as early as 4-8 h p.i., in rats injected with MBP-specific as in animals injected with ovalbumin-specific T cell lines, suggesting a non-specific mechanism. Experimental MRI may become a powerful tool to sequentially analyse changes in barrier dynamics, for example following pharmacological intervention. |
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Authors:
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P A Seeldrayers; J Syha; S P Morrissey; H Stodal; K Vass; S Jung; T Gneiting; H Lassmann; A Haase; H P Hartung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 46 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-09-28 Completed Date: 1993-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 199-206 Citation Subset: IM |
Affiliation:
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Neurologische Klinik, Julius-Maximilians-Universität Würzburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier* Brain / pathology Encephalomyelitis, Autoimmune, Experimental / cerebrospinal fluid, immunology, pathology* Female Immunization, Passive Magnetic Resonance Imaging Rats Rats, Inbred Lew Time Factors |
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