Document Detail


Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis.
MedLine Citation:
PMID:  8360329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent advances in fast magnetic resonance imaging (MRI) techniques have allowed quantification of parameters such as T1 relaxation time, which can be modified by changes in the water content of a tissue. We have used this new method to study the evolution of blood-brain barrier (BBB) changes after adoptive transfer of MBP-specific (AT-EAE) and ovalbumin-specific T cell lines in Lewis rats. Measurable changes in T1 relaxation time suggesting widespread increase in BBB permeability were found, starting on day 3 post inoculation (p.i.), in the midbrain and brainstem of AT-EAE rats. In addition, we noted a significant decrease in T1 relaxation time before injection of a paramagnetic agent, in the cisternal cerebrospinal fluid (CSF) of diseased animals, starting on day 5 p.i. In vitro measurement of T1 in CSF containing various concentrations of albumin, IgM and glucose showed that, at physiological concentrations, a T1 decrease is mainly associated with an increase in albumin concentration. A moderate increase in BBB and blood-CSF barrier permeability was found as early as 4-8 h p.i., in rats injected with MBP-specific as in animals injected with ovalbumin-specific T cell lines, suggesting a non-specific mechanism. Experimental MRI may become a powerful tool to sequentially analyse changes in barrier dynamics, for example following pharmacological intervention.
Authors:
P A Seeldrayers; J Syha; S P Morrissey; H Stodal; K Vass; S Jung; T Gneiting; H Lassmann; A Haase; H P Hartung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  46     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Affiliation:
Neurologische Klinik, Julius-Maximilians-Universität Würzburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood-Brain Barrier*
Brain / pathology
Encephalomyelitis, Autoimmune, Experimental / cerebrospinal fluid,  immunology,  pathology*
Female
Immunization, Passive
Magnetic Resonance Imaging
Rats
Rats, Inbred Lew
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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