Document Detail

Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome.
MedLine Citation:
PMID:  16770663     Owner:  NLM     Status:  MEDLINE    
Neonatal MR imaging is invaluable in assessing the term born neonate who presents with an encephalopathy. Successful imaging requires adaptations to both the hardware and the sequences used for adults. The perinatal and postnatal details often predict the pattern of lesions sustained and are essential for correct interpretation of the imaging findings, but additional or alternative diagnoses in infants with apparent hypoxic ischaemic encephalopathy should always be considered. Perinatally acquired lesions are usually at their most obvious between 1 and 2 weeks of age. Very early imaging (<3 days) may be useful to make management decisions in ventilated neonates, but abnormalities may be subtle at that stage. Diffusion-weighted imaging is clinically useful for the early identification of ischaemic white matter in the neonatal brain but is less reliable in detecting lesions within the basal ganglia and thalami. The pattern of lesions seen on MRI can predict neurodevelopmental outcome. Additional useful information may be obtained by advanced techniques such as MR angiography, venography and perfusion-weighted imaging. Serial imaging with quantification of both structure size and tissue damage provides invaluable insights into perinatal brain injury.
Mary Rutherford; Latha Srinivasan; Leigh Dyet; Phil Ward; Joanna Allsop; Serena Counsell; Frances Cowan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-05-16
Journal Detail:
Title:  Pediatric radiology     Volume:  36     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2007-01-30     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  582-92     Citation Subset:  IM    
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MeSH Terms
Brain / embryology,  pathology*
Brain Injuries / diagnosis*
Hypoxia-Ischemia, Brain / diagnosis
Infant, Newborn
Magnetic Resonance Imaging / methods*
Grant Support
MC_U120088465//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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