| Magnetic resonance imaging guided catheterisation for assessment of pulmonary vascular resistance: in vivo validation and clinical application in patients with pulmonary hypertension. | |
| | |
MedLine Citation:
|
PMID: 16020598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To validate in vivo a magnetic resonance imaging (MRI) method for measurement of pulmonary vascular resistance (PVR) and subsequently to apply this technique to patients with pulmonary hypertension (PHT). METHODS AND RESULTS: PVR was assessed from velocity encoded cine MRI derived pulmonary artery (PA) flow volumes and simultaneously determined invasive PA pressures. For pressure measurements flow directed catheters were guided under magnetic resonance fluoroscopy at 1.5 T into the PA. In preliminary validation studies (eight swine) PVR was determined with the thermodilution technique and compared with PVR obtained by MRI (0.9 (0.5) v 1.1 (0.3) Wood units.m2, p = 0.7). Bland-Altman test showed agreement between both methods. Inter-examination variability was high for thermodilution (6.2 (2.2)%) but low for MRI measurements (2.1 (0.3)%). After validation, the MRI method was applied in 10 patients with PHT and five controls. In patients with PHT PVR was measured at baseline and during inhalation of nitric oxide. Compared with the control group, PVR was significantly increased in the PHT group (1.2 (0.8) v 13.1 (5.6) Wood units.m2, p < 0.001) but decreased significantly to 10.3 (4.6) Wood units.m2 during inhalation of nitric oxide (p < 0.05). Inter-examination variability of MRI derived PVR measurements was 2.6 (0.6)%. In all experiments (in vivo and clinical) flow directed catheters were guided successfully into the PA under MRI control. CONCLUSIONS: Guidance of flow directed catheters into the PA is feasible under MRI control. PVR can be determined with high measurement precision with the proposed MRI technique, which is a promising tool to assess PVR in the clinical setting. |
| | |
Authors:
|
T Kuehne; S Yilmaz; I Schulze-Neick; E Wellnhofer; P Ewert; E Nagel; P Lange |
Related Documents
:
|
19339918 - The role of mri in rheumatoid arthritis: research and clinical issues. 20830248 - Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopath... 4073738 - Magnetic resonance imaging findings and correlations in spasmodic dysphonia patients. 2372728 - Magnetic resonance imaging and computed tomography of an intraventricular craniopharyng... 2555018 - Small hepatocellular carcinoma: detection with sonography, computed tomography (ct), an... 12790988 - Endoanal ultrasound or magnetic resonance imaging for preoperative assessment of anal f... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 91 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-07-15 Completed Date: 2005-08-22 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 1064-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Congenital Heart Diseases and Paediatric Cardiology, German Heart Institute, Berlin, Germany. kuehne@dhzb.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Blood Flow Velocity / physiology Blood Pressure / physiology Heart Catheterization / methods* Humans Hypertension, Pulmonary / physiopathology* Magnetic Resonance Imaging, Cine / standards* Nitric Oxide / pharmacology Swine Vascular Resistance / physiology* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
|
Heart. 2005 Aug;91(8):995-6
[PMID:
16020579
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Implantation of endovascular stents for the obstructive right ventricular outflow tract.
Next Document: Timing of presentation and postnatal outcome of infants suspected of having coarctation of the aorta...