Document Detail


Magnetic resonance imaging determination of cardiac prognosis.
MedLine Citation:
PMID:  12403662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Regional assessments of left ventricular (LV) wall motion obtained during MRI cardiac stress tests can be used to identify myocardial injury and ischemia, but the utility of MRI stress test results for the assessment of cardiac prognosis is not known. METHODS AND RESULTS: Two hundred seventy-nine patients referred (because of poor LV endocardial visualization with echocardiography) for dobutamine/atropine MRI for the detection of inducible ischemia were followed for an average of 20 months. After MRI stress testing, the occurrence of myocardial infarction, cardiac death, death attributable to any cause, coronary arterial revascularization, and unstable angina or congestive heart failure requiring hospitalization was determined. In a multivariate analysis, the presence of inducible ischemia (hazard ratio 3.3, CI 1.1 to 9.7) or an LV ejection fraction <40% (hazard ratio 4.2, CI 1.3 to 13.9) was associated with future MI or cardiac death independent of the presence of risk factors for coronary arteriosclerosis. CONCLUSIONS: In patients with poor echocardiograms, the results of cardiac MRI stress tests can be used to forecast myocardial infarction or cardiac death.
Authors:
W Gregory Hundley; Timothy M Morgan; Christina M Neagle; Craig A Hamilton; Pairoj Rerkpattanapipat; Kerry M Link
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  106     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2002-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2328-33     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine (Cardiology Section), Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA. ghundley@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Atropine / diagnostic use
Death, Sudden, Cardiac / etiology,  prevention & control
Disease-Free Survival
Dobutamine / diagnostic use
Exercise Test
Female
Follow-Up Studies
Heart Diseases / complications,  diagnosis*
Heart Function Tests
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Myocardial Infarction / etiology,  prevention & control
Myocardial Ischemia / diagnosis,  etiology
Odds Ratio
Predictive Value of Tests
Prognosis
Risk Assessment
Stroke Volume
Ventricular Function, Left
Grant Support
ID/Acronym/Agency:
3-M01-RR07122-08S1/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
34368-04-2/Dobutamine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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