Document Detail


Magnetic resonance imaging of childhood Guillain-Barre syndrome.
MedLine Citation:
PMID:  20556395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the spinal magnetic resonance imaging (MRI) features in children with Guillain-Barre syndrome (GBS) and to investigate the correlation with the clinical/laboratory findings. MATERIAL AND METHODS: Clinical/laboratory findings of 40 children (mean age 5.7 years; range, 3 months-15 years) who had a final diagnosis of GBS were retrospectively reviewed. Clinical severity was graded according to Hughes classification. Electromyogram and cerebrospinal fluid analysis of the patients were recorded. All patients had a contrast-enhanced spinal MRI. The contrast enhancement pattern was determined, and the diameters of anterior and posterior spinal nerve roots were measured. The clinical/laboratory findings were correlated with the MRI findings. RESULTS: Twenty-eight patients had an electromyogram examination, and 25 of them revealed findings consistent with GBS. Cerebrospinal fluid analysis of 37 out of 40 patients showed albumino-cytologic dissociation. All but two patients had thickening and contrast enhancement of the nerve roots and cauda equina on spinal MRI. The most common MRI finding was enhancement of both the anterior and the posterior nerve roots of cauda equina which was prominent anteriorly. The mean anteroposterior diameter of the anterior nerve roots was 2.19 mm (range, 1.38-3.30 mm) and the posterior nerve root was 1.80 mm (range, 1.07-2.97 mm). CONCLUSION: Spinal MRI is a reliable imaging method for the diagnosis of GBS as it was positive in 38 of 40 patients. The severity on MRI does not correlate with severity of the clinical condition. MRI can be used as a supplementary diagnostic modality to clinical and laboratory findings of GBS.
Authors:
Ali Yikilmaz; Selim Doganay; Hakan Gumus; Huseyin Per; Sefer Kumandas; Abdulhakim Coskun
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Publication Detail:
Type:  Journal Article     Date:  2010-06-17
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  26     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1103-8     Citation Subset:  IM    
Affiliation:
Department of Pediatric Radiology, Erciyes University, School of Medicine, Children's Hospital, Talas Yolu, 38039 Melikgazi, Kayseri, Turkey. dryikilmaz@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cauda Equina / pathology*
Child
Child, Preschool
Electromyography
Female
Guillain-Barre Syndrome / cerebrospinal fluid,  pathology*,  physiopathology
Humans
Infant
Magnetic Resonance Imaging*
Male
Retrospective Studies
Spinal Nerve Roots / pathology*
Comments/Corrections
Comment In:
Childs Nerv Syst. 2010 Sep;26(9):1135; author reply 1137   [PMID:  20644940 ]

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