| Magnetic resonance imaging of cerebral involutional changes in dogs as markers of aging: an innovative tool adapted from a human visual rating scale. | |
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MedLine Citation:
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PMID: 19748805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dog is increasingly considered as a natural animal model for the study of normal and pathological human brain aging, because it exhibits anatomical, biochemical and cognitive changes that parallel those seen in humans. This study presents a novel visual semi-quantitative rating scale of canine cerebral magnetic resonance imaging (MRI). Ninety-eight dogs of both sexes from 27 pure breeds, aged 2-15 years, were used. The results suggest that (like in humans) both hippocampal and progressive global atrophy are characteristic features that correlate with aging. When classified according to head shape, cerebral atrophy was highest in mesaticephalic and brachycephalic dogs. This is the first MRI study to characterise a simple, rapid tool for studying age-related canine brain changes that can even be applied by non-experienced observers. The results confirm the possibility of transferring innovative tools developed for human diagnosis to the veterinary field. |
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Authors:
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Marco Pugliese; Josep Lluís Carrasco; Beatriz Gomez-Anson; Carmen Andrade; Angels Zamora; Manuel José Rodríguez; Joan Mascort; Nicole Mahy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-12 |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 186 ISSN: 1532-2971 ISO Abbreviation: Vet. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Unitat de Bioquímica, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain. marcopugliese@ub.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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pathology* Animals Atrophy / pathology, veterinary Cerebrum / pathology* Diffusion of Innovation Disease Models, Animal Dogs Female Hippocampus / pathology Magnetic Resonance Imaging / methods, veterinary* Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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