Document Detail

Magnetic resonance imaging of the brain with gadopentetate dimeglumine-DTPA: comparison of T1-weighted spin-echo and 3D gradient-echo sequences.
MedLine Citation:
PMID:  8724406     Owner:  NLM     Status:  MEDLINE    
Short TR, short TE, high resolution, 3D gradient-recalled echo (GRE) imaging was evaluated for lesion detection in the brain. High resolution 3D GRE data acquisition was used to reduce partial volume effects and flow artifacts, to better visualize smaller structures, to minimize signal losses caused by field inhomogeneities, and to allow better image reformatting. Spin-echo (SE) and 3D GRE approaches were compared for lesion detection after the administration of an MR contrast agent, gadopentetate dimeglumine. Preliminary clinical studies demonstrated that the signal-to-noise ratio (SNR) in each slice of the GRE scan was worse than that of the SE scan because of the much thicker slices acquired with the SE technique. However, by averaging two adjacent 3D slices, the SNR of the two methods was essentially equivalent. In the averaged GRE slices, large lesions were seen just as well as in the SE images. More importantly, small lesions were better visualized in the thin 3D GRE images than in the thick SE images for the lesions studied in this work and the protocols used. These observations were confirmed by theoretical simulations.
D Li; E M Haacke; R W Tarr; R Venkatesan; W Lin; P Wielopolski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  6     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-24     Citation Subset:  IM    
Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 63110, USA.
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MeSH Terms
Brain / pathology*
Brain Diseases / diagnosis
Brain Neoplasms / diagnosis
Computer Simulation
Contrast Media*
Drug Combinations
Gadolinium DTPA
Image Enhancement / instrumentation*
Image Processing, Computer-Assisted / instrumentation*
Magnetic Resonance Angiography / instrumentation
Magnetic Resonance Imaging / methods*
Meglumine / diagnostic use*
Middle Aged
Organometallic Compounds / diagnostic use*
Pentetic Acid / analogs & derivatives*,  diagnostic use
Sensitivity and Specificity
Grant Support
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 0/Organometallic Compounds; 6284-40-8/Meglumine; 67-43-6/Pentetic Acid; 80529-93-7/Gadolinium DTPA

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