Document Detail


Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia nigra in patients with Parkinson's disease.
MedLine Citation:
PMID:  16462479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Parkinson's disease (PD) is associated with well-documented morphological changes in substantia nigra and basal ganglia nuclei. This study evaluates the ability of magnetic resonance imaging to detect these changes and investigates the relationship between severity of clinical findings and degree of morphological change. This correlation may provide valuable information in early diagnosis of PD. METHODS: Sixteen patients with early stage PD, eight patients with advanced PD, and eight normal controls were studied by 3T magnetic resonance imaging. The whole brain volume and the volumes of the caudate, putamen, globus pallidus, and substantia nigra were calculated on three-dimensional reconstructed images. RESULTS: Putamen volume was significantly diminished in patients with early PD and advanced PD compared with that in controls (P < 0.05), and the percentage of atrophy was 12.5 and 26.5%, respectively. The putamen volume was negatively correlated with Hoehn and Yahr staging (r = -0.720, P < 0.001). Pallidal volume was reduced only in advanced PD (P = 0.023). There were no significant differences in total brain, caudate, or substantia nigra among these three groups CONCLUSION: Magnetic resonance imaging-based volumetric measurement is a sensitive method in the assessment of morphological changes of PD in vivo. The putamen atrophy was correlated with the severity of clinical findings. The volumetric measurement of putamen could potentially be a useful indicator of PD in the early stage.
Authors:
Dao-Ying Geng; Yu-Xin Li; Chi-Shing Zee
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  58     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-62; discussion 256-62     Citation Subset:  IM    
Affiliation:
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrophy
Basal Ganglia / pathology*
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Organ Size
Parkinson Disease / pathology*
Putamen / pathology
Substantia Nigra / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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