| Magnetic resonance imaging appearance and changes on intracavitary Gliadel wafer placement: A pilot study. | |
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MedLine Citation:
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PMID: 22132297 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: To investigate changes on magnetic resonance imaging (MRI) which occur with intracavitary Gliadel wafer placement in patients with glioblastoma multiforme (GBM). METHODS: This retrospective Health Insurance Portability and Accountability Act-compliant study was approved by the institutional review board, with a waiver of informed consent. A total of eight patients aged 29-67 years with GBM underwent Gliadel wafer placement. T2-weighted/FLAIR images and post-contrast T1-weighted images both before and after wafer placement were retrospectively reviewed in consensus to determine changes in the following parameters: appearance of the pericavitary tissue, pattern of tumor recurrence or progression and appearance of the Gliadel wafer itself. RESULTS: Five out of the eight patients had a progressive increase in enhancement and pericavitary T2/ FLAIR hyperintensity within the first 2 mo and a subsequent decrease in these MRI findings. None of these patients had tumor recurrence within the first 6 mo. Three out of the eight patients demonstrated a progressive increase in enhancement and pericavitary T2 hyperintensity, which continued after the first 6 mo, and were subsequently diagnosed with true tumor progression. There was no increase in distant/nonlocal tumor recurrence. The Gliadel wafer appearance changed over time. CONCLUSION: Pseudoprogression is common after intracavitary Gliadel wafer placement and thus care should be taken before diagnosing tumor progression or recurrence within the first 2 mo. |
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Authors:
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Rivka R Colen; Pascal O Zinn; Saman Hazany; Daniel Do-Dai; Julian K Wu; Kevin Yao; Jay J Zhu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of radiology Volume: 3 ISSN: 1949-8470 ISO Abbreviation: World J Radiol Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101538184 Medline TA: World J Radiol Country: China |
Other Details:
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Languages: eng Pagination: 266-72 Citation Subset: - |
Affiliation:
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Rivka R Colen, Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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