Document Detail

Magnetic resonance imaging (MRI) assessment of ventricular remodeling after myocardial infarction in rabbits.
MedLine Citation:
PMID:  22546917     Owner:  NLM     Status:  MEDLINE    
To understand the structure-function relationship in the postinfarcted myocardium in rabbits, we induced cardiac ischemia by ligating the left circumflex coronary artery. Sham controls underwent thoracotomy only. At 7 and 30 d after ligation, cardiac MRI was conducted by using pulse-oxymetry-gated cine acquisition to provide complete phases of the heartbeat. The rabbits were anesthetized under 1.5% isoflurane ventilation, and ultrafast techniques made breath-hold 3D coverage in different cardiac axes feasible. Viability imaging was performed after intravenous injection of 0.15 mmol/kg gadolinium to assess the extent of infarction. Data (n ≥ 6) are presented as mean ± SEM and analyzed by ANOVA and ANCOVA. In postligation rabbits, end-systolic (mean ± SEM, 2.3 ± 0.3 mL) and end-diastolic (4.2 ± 0.4 mL) volumes were increased compared with preligation values (end-systolic, 1.1 ± 0.1 mL; end-diastolic, 2.98 ± 0.2 mL). Ejection fraction was influenced adversely by the presence of scar tissue at both 7 and 30 d after ligation and apparently nonlinear with the heart rate. Cardiac force was increased in the basal region in both end-systole and end-diastole in postligation hearts but progressively decreased toward the apex. Late gadolinium enhancement delineated 15.2 ± 5.8% myocardial infarction at 7 d after ligation and 14.5 ± 5.8% at 30 d, with limited wall motion and wall thinness. Compensatory wall thickening was present in the basal region when compared with that in preligation hearts. MRI offers detailed spatial resolution and tissue characterization after myocardial infarction.
Norman Hu; Kyle H Sabey; Heather R Curtis; Nguyen Hoang; Spencer B Dowdle; Aida A Garzarelli; Henry R Buswell; Edward Dibella; James W Yockman; David A Bull
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Comparative medicine     Volume:  62     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-09-20     Revised Date:  2013-08-05    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-23     Citation Subset:  IM    
Division of Cardiothoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Analysis of Variance
Contrast Media / diagnostic use
Disease Models, Animal
Heart Rate
Magnetic Resonance Imaging, Cine*
Meglumine / analogs & derivatives,  diagnostic use
Myocardial Contraction
Myocardial Infarction / pathology*,  physiopathology
Myocardium / pathology*
Organometallic Compounds / diagnostic use
Predictive Value of Tests
Stroke Volume
Time Factors
Ventricular Function, Left
Ventricular Remodeling*
Grant Support
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 15G12L5X8K/gadobenic acid; 6284-40-8/Meglumine
Comment In:
Comp Med. 2013 Jun;63(3):205   [PMID:  23759521 ]
Comp Med. 2013 Jun;63(3):205   [PMID:  23759522 ]

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