| Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice. | |
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MedLine Citation:
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PMID: 16367864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo imaging of small animals is a rapidly developing field. However, the potential of global imaging of infectious processes in animal models remains poorly explored. We used magnetic resonance imaging (MRI) to follow the development and regression of inflammatory lesions caused by infection by Klebsiella pneumoniae in mouse lungs. A virulent strain caused an intense inflammation within 2 days in the whole lungs, while an avirulent strain did not show significant changes. Mice infected with the virulent strain and subsequently treated with antibiotics presented a severe inflammation localized mainly in the left lung that disappeared after a week. The lesions observed by MRI correlated with the damage seen by histological analysis and a 3D representation of the tissue allowed better visualization of the development and healing of inflammatory lesions. MRI thus represents a powerful technique to study in vivo the interactions between a pathogen and its host in real time. |
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Authors:
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Régis Tournebize; Bich-Thuy Doan; Marie-Agnès Dillies; Sabine Maurin; Jean-Claude Beloeil; Philippe J Sansonetti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular microbiology Volume: 8 ISSN: 1462-5814 ISO Abbreviation: Cell. Microbiol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-21 Completed Date: 2006-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 33-43 Citation Subset: IM |
Affiliation:
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Pathogénie Microbienne Moléculaire - INSERM 389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France. tournebi@pasteur.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Klebsiella pneumoniae / pathogenicity* Lung / microbiology, pathology* Magnetic Resonance Imaging Mice Mice, Inbred BALB C Pneumonia, Bacterial / microbiology, pathology* |
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