| Magnetic resonance-guided angioplasty with delivery of contrast-media doped solutions to the vessel wall: an experimental study in swine. | |
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MedLine Citation:
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PMID: 18580336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the feasibility of magnetic resonance (MR)-guided delivery of a solution containing contrast-medium and immediate online monitoring of its distribution to the vessel wall during MR-guided angioplasty in peripheral arteries. MATERIALS AND METHODS: In 3 pigs, the feasibility of MR-guided atraumatic delivery of a solution containing contrast-medium and tissue dye (0.05 mmol/mL Gd-DTPA, 3% Evans blue dye) into the vessel wall of the iliac arteries was tested using a permeable balloon catheter (8 mm). Catheter placement was monitored using a steady-state free precession real-time imaging sequence.Additionally, in 5 pigs, surgically created bilateral stenoses in the external iliac artery were dilatated with the porous balloon. In these animals, contrast-enhanced MR angiography was performed before and after the interventions to assess the degree of the stenosis. In all animals, the vessel wall was delineated before and after dilatation using a T1-weighted gradient echo (GE) sequence. RESULTS: In the 3 animals without stenosis, contrast medium was successfully applied to the vessel wall. On the GE images, the normalized signal intensity of the vessel wall was 0.95 +/- 0.015 arbitrary units (a. u.) prior and 2.15 +/- 0.105 a. u. after the intervention (P < 0.01). In the animals with stenosis, MR angiography performed before and after the intervention demonstrated successful dilatation of 9 of the 10 stenoses. Before the intervention, 7 stenoses were severe (76%-99%) and 3 moderate (50%-75%), and after the intervention, 4 stenoses were completely removed and 5 mild (<50%). Also in these 5 animals, the solution was visible in the vessel wall of the arteries on the T1-weighted GE MR images (normalized signal intensity prior the intervention 1.33 +/- 0.16 a. u. and 2.97 +/- 0.23 after angioplasty; P < 0.05). Histology demonstrated the distribution of the Evan's blue dye within the vessel wall in all animals. CONCLUSIONS: MR-guided delivery of a contrast-medium containing solution and immediate online assessment of its distribution to the vessel wall during angioplasty in peripheral arteries is feasible. |
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Authors:
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Gabriele A Krombach; Martin Wehner; Alberto Perez-Bouza; Linda Kaimann; Sylvia Kinzel; Thorsten Plum; Daniel Schibur; Michael Friebe; Rolf W Günther; Christian Hohl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 43 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-26 Completed Date: 2008-09-05 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 530-7 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University Hospital, Aachen, Germany. krombach@rad.rwth-aachen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty
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methods* Animals Contrast Media / administration & dosage Feasibility Studies Gadolinium DTPA / administration & dosage*, diagnostic use* Iliac Artery / anatomy & histology*, surgery* Image Enhancement / methods Magnetic Resonance Imaging, Interventional / methods* Surgery, Computer-Assisted / methods* Swine Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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