| Magnetic resonance elastography of the liver: preliminary results and estimation of inter-rater reliability. | |
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MedLine Citation:
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PMID: 20972864 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to estimate inter-rater reliability and validate magnetic resonance elastography (MRE) as a tool to measure liver elasticity. MATERIALS AND METHODS: The study protocol was approved by the institutional review board at our institution. In all, 10 normal volunteers and 110 patients, who provided written informed consent, were enrolled. The pathological fibrosis score was applied as a standard reference of liver fibrosis in 21 patients. MRE was performed with a 1.5-T magnetic resonance imaging scanner with a cylindrical passive longitudinal shear wave driver placed over the right chest wall to deliver vibrations. A gradient-echo MRE sequence was used to acquire axial wave images, which were automatically converted to elastograms representing elasticity (in kilopascals, or kPa). The region of interest was placed in the right lobe of the liver on elastograms by two raters independently. To evaluate interrater reliability, the intraclass correlation coefficient was calculated. The elasticity measurements correlated with the pathological fibrosis score (F1-F4) in 21 patients. RESULTS: The intraclass correlation coefficient was almost perfect (0.993) between the elasticities measured by the two raters. The mean elasticity value for patients with F4 was 5.7 kPa; F3, 4.4 kPa; F2, 3.1 kPa; F1, 2.2 kPa; and F0, 2.1 kPa. CONCLUSION: MRE is a reliable tool to measure liver elasticity. |
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Authors:
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Utaroh Motosugi; Tomoaki Ichikawa; Katsuhiro Sano; Hironobu Sou; Ali Muhi; Tsuyota Koshiishi; Richard L Ehman; Tsutomu Araki |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-24 |
Journal Detail:
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Title: Japanese journal of radiology Volume: 28 ISSN: 1867-108X ISO Abbreviation: Jpn J Radiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490689 Medline TA: Jpn J Radiol Country: Japan |
Other Details:
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Languages: eng Pagination: 623-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Yamanashi, Shimokato, Chuo, Japan. utaroh-motosugi@nifty.com |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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EB001981/EB/NIBIB NIH HHS |
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