| Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study. | |
| | |
MedLine Citation:
|
PMID: 22209496 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS). OBJECTIVE: Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change. METHODS: We studied 84 MS patients over a 3.2±0.3year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF. RESULTS: Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing-remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038). CONCLUSION: Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS. |
| | |
Authors:
|
Jennifer Moodie; Brian C Healy; Guy J Buckle; Susan A Gauthier; Bonnie I Glanz; Ashish Arora; Antonia Ceccarelli; Shahamat Tauhid; Xue-Mei Han; Arun Venkataraman; Tanuja Chitnis; Samia J Khoury; Charles R G Guttmann; Howard L Weiner; Mohit Neema; Rohit Bakshi |
Related Documents
:
|
1529136 - Beam's eye view--based radiation therapy: description of methods. 22254786 - Path-loss estimation of wireless channels in capsule endoscopy from x-ray ct images. 22086346 - Cost-effectiveness analysis of polymyxin-b immobilized fiber column and conventional me... 22159696 - Colonic bowel wall thickening: is there a need for endoscopic evaluation? 16855816 - Biological applications of scanning electrochemical microscopy: chemical imaging of sin... 20107796 - Clearance of the high intestinal (18)f-fdg uptake associated with metformin after stopp... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: - ISSN: 1878-5883 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Neurology, University of Massachusetts, Boston, MA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative study of skeletal stability between bicortical resorbable and titanium screw fixation af...
Next Document: Frequency domain optical coherence tomography for guidance of coronary stenting.