Document Detail

Magnetic resonance diffusion tensor imaging and tractography of the lower spinal cord: application to diastematomyelia and tethered cord.
MedLine Citation:
PMID:  20432039     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the feasibility of routine clinical DTI of the lower spinal cord using high-field-strength MRI and parallel imaging, and to evaluate the utility of diffusion tensor imaging and tractography as tools for study of lower cord pathology.
METHODS: Three patients with diastematomyelia, one patient with tethered cord, and six normal volunteers underwent MR imaging of the lower spine at 3 T. A 15-channel spine coil and parallel imaging were used with a six-direction single-shot echo-planar gradient echo technique.
RESULTS: In normal volunteers, tractography delineated the conus and cauda equina. Tractography software permitted assessment of fractional anisotropy of the distal cord and nerve roots. In cases of tethered cord, tractography correlated with anatomical imaging. Tractography also correlated with the anatomical pathological findings in cases of diastematomyelia.
CONCLUSIONS: The methods described enable routine DTI and tractography of the lower spinal cord at 3 T. Compared with conventional imaging, tractography offers additional information that may prove useful in the characterization and surgical planning for congenital lesions involving the lower spinal cord.
Christopher G Filippi; Trevor Andrews; Jay V Gonyea; Grant Linnell; Keith A Cauley
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Publication Detail:
Type:  Journal Article     Date:  2010-04-30
Journal Detail:
Title:  European radiology     Volume:  20     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2194-9     Citation Subset:  IM    
Department of Radiology, Fletcher Allen Healthcare, University of Vermont College of Medicine, Burlington, VT 05401, USA.
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MeSH Terms
Diffusion Tensor Imaging / methods*
Lumbar Vertebrae / pathology
Middle Aged
Neural Tube Defects / pathology*
Spinal Cord / pathology*

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