Document Detail


Magnetic resonance colonography without bowel cleansing: a prospective cross sectional study in a screening population.
MedLine Citation:
PMID:  17341542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: To evaluate the diagnostic accuracy of magnetic resonance colonography (MRC) without bowel cleansing in a screening population and compare the results to colonoscopy as a standard of reference.
METHODS: 315 screening patients, older than 50 years with a normal risk profile for colorectal cancer, were included in this study. For MRC, a tagging agent (5.0% Gastrografin, 1.0% barium sulphate, 0.2% locust bean gum) was ingested with each main meal within 2 days prior to MRC. No bowel cleansing was applied. For the magnetic resonance examination, a rectal water enema was administered. Data collection was based on contrast enhanced T1 weighted images and TrueFISP images. Magnetic resonance data were analysed for image quality and the presence of colorectal lesions. Conventional colonoscopy and histopathological samples served as reference.
RESULTS: In 4% of all colonic segments, magnetic resonance image quality was insufficient because of untagged faecal material. Adenomatous polyps >5 mm were detected by means of MRC, with a sensitivity of 83.0%. Overall specificity was 90.2% (false positive findings in 19 patients). However, only 16 of 153 lesions <5 mm and 9 of 127 hyperplastic polyps could be visualised on magnetic resonance images.
CONCLUSIONS: Faecal tagging MRC is applicable for screening purposes. It provides good accuracy for the detection of relevant (ie, adenomatous) colorectal lesions >5 mm in a screening population. However, refinements to optimise image quality of faecal tagging are needed.
Authors:
Christiane A Kuehle; Jost Langhorst; Susanne C Ladd; Thomas Zoepf; Michael Nuefer; Florian Grabellus; Joerg Barkhausen; Guido Gerken; Thomas C Lauenstein
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-06
Journal Detail:
Title:  Gut     Volume:  56     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-12     Completed Date:  2007-08-06     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  1079-85     Citation Subset:  AIM; IM    
Affiliation:
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany. christiane.kuehle@uni-due.de
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MeSH Terms
Descriptor/Qualifier:
Adenoma / diagnosis,  pathology
Aged
Aged, 80 and over
Colon / pathology*
Colonoscopy / methods
Colorectal Neoplasms / diagnosis*,  pathology
Contrast Media
Cross-Sectional Studies
Diatrizoate Meglumine / diagnostic use
Feces
Female
Humans
Hyperplasia / diagnosis,  pathology
Intestinal Polyposis / diagnosis,  pathology
Magnetic Resonance Imaging / methods*
Male
Mass Screening / methods
Middle Aged
Prospective Studies
Reference Standards
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Contrast Media; 131-49-7/Diatrizoate Meglumine
Comments/Corrections

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