Document Detail

Magnetic resonance cholangiography for evaluation of cholestatic jaundice in neonates and infants.
MedLine Citation:
PMID:  9830280     Owner:  NLM     Status:  MEDLINE    
Distinguishing extrahepatic biliary atresia from other causes of cholestasis in neonates and infants is important because surgical intervention before 2 months of age allows for long-term survival. The purpose of this prospective study was to evaluate the usefulness of magnetic resonance (MR) cholangiography in differentiating biliary atresia from other causes of cholestatic jaundice in neonates and infants. Nine anicteric infants (control group) aged 10 to 224 days (mean +/- SD, 8 +/- 65 days) and 15 neonates and infants with cholestatic jaundice, aged 22 to 142 days (mean +/- SD, 71 +/- 37) underwent MR cholangiography. The final diagnosis of extrabiliary atresia (6 patients) was based on laparotomy findings (4 patients) or autopsy (2 patients), while neonatal hepatitis (9 patients) was diagnosed according to the liver biopsy findings and clinical recovery during follow-up. Percutaneous liver biopsies were performed in all 15 patients. Results showed that the gall bladder and common bile duct (CBD) could be visualized using MR cholangiography in all patients in the control group. Nonvisualization of the CBD (6/6 patients) and demonstration of a small gall bladder (6/6 patients) characterized MR cholangiography findings in patients with biliary atresia. MR cholangiography failed to depict the CBD in one infant with hepatitis. We conclude that demonstration of the CBD by MR cholangiography in neonates and infants with cholestasis can be used to exclude the diagnosis of biliary atresia. In patients with cholestatic jaundice considered for exploratory laparotomy, preoperative MR cholangiography is recommended to avoid unnecessary surgery.
S S Peng; Y W Li; M H Chang; Y H Ni; C T Su
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  97     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-05     Completed Date:  1999-01-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  698-703     Citation Subset:  IM    
Department of Medical Imaging, Medical College and Hospital, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Biliary Atresia / diagnosis
Cholestasis / diagnosis*
Common Bile Duct / pathology
Diagnosis, Differential
Gallbladder / pathology
Infant, Newborn
Magnetic Resonance Imaging*
Prospective Studies

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