| Magnetic resonance angiography of thromboembolic stroke in rats: indicator of recanalization probability and tissue survival after recombinant tissue plasminogen activator treatment. | |
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MedLine Citation:
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PMID: 12045663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance angiography (MRA) was performed in a thromboembolic stroke model of the rat to characterize intracranial vessel occlusion patterns and to test its predictive power for tissue recovery after recombinant tissue plasminogen activator (rt-PA) treatment. After rt-PA-treated selective middle cerebral artery (MCA) occlusion, full recanalization was observed in two of three animals, whereas additional occlusion of the circle of Willis (CW) resulted in full vascular flow restitution in only one of six rats. Tissue reperfusion markedly lagged the onset of treatment, and the delay correlated with the pattern of vessel occlusion (20 to 23 minutes for selective MCA occlusion vs. 71 to 79 minutes for combined MCA/CW occlusion). In lateral cortex and striatum the apparent diffusion coefficient decreased to 78 +/- 15% of control after embolization, recovered to 80% to 85% after rt-PA treatment of selective MCA occlusion, but further declined to 66% to 69% after combined MCA/CW occlusion. Correspondingly, T2 relaxation time increased to 107% to 118% of control after selective MCA occlusion and to 112% to 124% after combined MCA/CW occlusion in these regions. The present investigation shows that MRA provides valuable information on the severity of thromboembolic stroke and has the power to predict, before the initiation of treatment, the functional tissue outcome after rt-PA-induced thrombolysis. |
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Authors:
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Thomas Hilger; Frank Niessen; Michael Diedenhofen; Konstantin-Alexander Hossmann; Mathias Hoehn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 22 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-04 Completed Date: 2002-07-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 652-62 Citation Subset: IM |
Affiliation:
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Department of Experimental Neurology, Max-Planck-Institute for Neurological Research, Köln, Germany. hilger@mpin-koeln.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Edema / diagnosis, drug therapy, pathology Cerebral Revascularization Cerebrovascular Circulation / drug effects Fibrinolytic Agents / pharmacology* Infarction, Middle Cerebral Artery / diagnosis*, drug therapy*, pathology Intracranial Thrombosis / diagnosis*, drug therapy*, pathology Magnetic Resonance Angiography Male Predictive Value of Tests Rats Rats, Wistar Thromboembolism / diagnosis, drug therapy, pathology Tissue Plasminogen Activator / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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