| Magnetic nanoparticle transport within flowing blood and into surrounding tissue. | |
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MedLine Citation:
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PMID: 21128726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic drug delivery refers to the physical confinement of therapeutic magnetic nanoparticles to regions of disease, tumors, infections and blood clots. Predicting the effectiveness of magnetic focusing in vivo is critical for the design and use of magnetic drug delivery systems. However, current simple back-of-the-envelope estimates have proven insufficient for this task. In this article, we present an analysis of nanoparticle distribution, in and around a single blood vessel (a Krogh tissue cylinder), located at any depth in the body, with any physiologically relevant blood flow velocity, diffusion and extravasation properties, and with any applied magnetic force on the particles. For any such blood vessel our analysis predicts one of three distinct types of particle behavior (velocity dominated, magnetic dominated or boundary-layer formation), which can be uniquely determined by looking up the values of three nondimensional numbers we define. We compare our predictions to previously published magnetic-focusing in vitro and in vivo studies. Not only do we find agreement between our predictions and prior observations, but we are also able to quantitatively explain behavior that was not understood previously. |
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Authors:
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A Nacev; C Beni; O Bruno; B Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: 5 ISSN: 1748-6963 ISO Abbreviation: Nanomedicine (Lond) Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-28 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1459-66 Citation Subset: IM |
Affiliation:
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Fischell Department of Bioengineering, University of Maryland at College Park, MD, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology* Drug Delivery Systems Humans Magnetics* Nanoparticles* |
| Grant Support | |
ID/Acronym/Agency:
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R21 EB009265-01A2/EB/NIBIB NIH HHS; R21EB009265/EB/NIBIB NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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