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Magnetic microcapsules as novel biomonitors of cross-linking agents and diet-dependent reactive oxygen species in the human gastrointestinal tract.
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MedLine Citation:
PMID:  8319647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six healthy, scientifically informed human volunteers were given 14C-labeled polyethyleneimine (PEI) microcapsules by mouth. Fecal 14C recovery was inversely related to mean gut transit time (r = -0.66), and the extent of cross-linking between the membrane and core PEI was inversely related to total fecal output (r = -0.81). Cross-linking of PEI microcapsules may be a biomonitor of endogenous cross-linking agents within the human gastrointestinal tract. Extensive loss of [14C]CH3 label occurred from the microcapsules during human transit and in in vitro fermentations with human fecal flora. A mechanism whereby reactive oxygen species could arise in the iron-rich core of these microcapsules, leading to loss of [14C]CH3 label, is proposed.
Authors:
S A Bingham; A B Shah; A Ellul; J H Cummings; I K O'Neill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  99     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Affiliation:
MRC Dunn Clinical Nutrition Centre, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Capsules
Cross-Linking Reagents / metabolism*
DNA Damage
Diet
Digestive System / metabolism*
Environmental Monitoring / methods*
Female
Humans
Magnetics
Male
Middle Aged
Polyethyleneimine
Reactive Oxygen Species / metabolism*
Chemical
Reg. No./Substance:
0/Capsules; 0/Cross-Linking Reagents; 0/Reactive Oxygen Species; 9002-98-6/Polyethyleneimine
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 3 Year: 1993
Volume: 99First Page: 293 Last Page: 295
ID: 1567072
PubMed Id: 8319647

Magnetic microcapsules as novel biomonitors of cross-linking agents and diet-dependent reactive oxygen species in the human gastrointestinal tract.
S A Bingham
A B Shah
A Ellul
J H Cummings
I K O'Neill
MRC Dunn Clinical Nutrition Centre, Cambridge, UK.



Article Categories:
  • Research Article


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