Document Detail

Magnetic field-like fluid circulation of a porous orifice tube and its relevance to the capillary-interstitial fluid circulation: preliminary report.
MedLine Citation:
PMID:  11359355     Owner:  NLM     Status:  MEDLINE    
In 1886, Starling proposed a hypothesis for the capillary-interstitial fluid transfer in which capillary filtration is attributed to arterial pressure, based on Poiseuille's work in long uniform tubes. In 1967-8, the precapillary sphincter, pores and negative interstitial pressure were reported. In 1984, clinical observations inconsistent with Starling's hypothesis prompted a physical study to verify pressure dynamics in a porous orifice (G) tubes. Results demonstrate that, unlike in Poiseuille's tube, a fluid passing inside the lumen of the G tube exerts a negative energy pressure gradient on its wall; most negative over its proximal part causing inflow of fluid by suction and positive over its distal part causing fluid outflow. A net negative pressure gradient also occurs in a surrounding chamber C, causing fluid to flow in an opposite direction to lumen flow. An autonomous dynamic magnetic field-like G-C circulation occurred between lumen and surrounding fluid compartments. Reviewed literature support the contention that this sole phenomenon adequately explains the capillary-interstitial fluid transfer under both physiological and pathological haemodynamic conditions.
A N Ghanem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  56     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-21     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  325-34     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
King Khalid Hospital, Najran, Kingdom of Saudi Arabia.
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MeSH Terms
Blood Circulation / physiology*
Capillaries / physiology*
Extracellular Space / physiology*
Models, Cardiovascular*

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