| Magnetic drug delivery and targeting: principles and applications. | |
| | |
MedLine Citation:
|
PMID: 20208962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Magnetic nanoparticles for cancer therapy and diagnosis have been developed on the basis of their unique physico-chemical properties not present in other materials. Their versatility is widely exploited in such diverse techniques as cell and macromolecule separation and purification, immunoassays, targeted drug delivery, controlled material release, electromagnetic hyperthermia, gene therapy, or magnetic resonance imaging. In this review we concentrate on the physical principles of magnetic drug targeting and biomedical applications of this technique. METHODS AND RESULTS: We examined several databases, PubMed, ISI Web of Knowledge, and Scopus, for the period 1985-2009, with specific attention to studies that used targeting of magnetic nanoparticles especially in the therapy and diagnostics of tumors. We have also presented several of our own results on theoretical simulations of magnetic particle motion in external magnetic field. CONCLUSIONS: We found growing number of published papers in this field of nanomedicine, showing the almost unlimited potential of magnetic nanoparticles in the field of experimental and clinical oncology. |
| | |
Authors:
|
Melania Babincova; Peter Babinec |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Biomedical papers of the Medical Faculty of the University Palack?, Olomouc, Czechoslovakia Volume: 153 ISSN: 1213-8118 ISO Abbreviation: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-03-08 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140142 Medline TA: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Country: Czech Republic |
Other Details:
|
Languages: eng Pagination: 243-50 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics, and Informatics, Comenius University, Mlynska dolina F1, Bratislava, Slovakia. babincova@fmph.uniba.sk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Computer Simulation Drug Delivery Systems* Ferric Compounds / diagnostic use, therapeutic use Finite Element Analysis Magnetics* Metal Nanoparticles Nanomedicine* Nanoparticles Neoplasms / diagnosis, drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Ferric Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffraction-free beams in thin films.
Next Document: Post-transplant lymphoproliferative disorder.