| Magnetic colloids as drug vehicles. | |
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MedLine Citation:
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PMID: 18064669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review article is a description of the present status of magnetic drug delivery systems (DDS). These are colloidal dispersions of composite nanoparticles consisting of a (polymeric or inorganic) biocompatible matrix and magnetic units, and designed to load and release therapeutic drugs. The matrix, together perhaps with adsorbed polymers or polyelectrolytes, provides the DDS with additional colloidal stability and eventually control of the immune response, and the magnetic inclusions have the goal of providing magnetic guidance. The techniques used in the production of the particles are described. The large surface/volume ratio of the particles brings about a superlative importance of the interface aspects, which are depicted in some detail. Attention is also paid to the possibilities that magnetic DDS offer to be guided by magnetic fields, and to their fate upon entering in contact with the blood proteins and the tumor cells. A description of in vitro and in vivo biodistribution experiments helps in this description. The number of animal experiments performed using magnetic DDS is rather large, but results in humans are far from being sufficient in number, something easily understood. The hopes for improvement and the challenges that must be overcome are described in the closing section. |
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Authors:
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J D G Durán; J L Arias; V Gallardo; A V Delgado |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 97 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2948-83 Citation Subset: IM |
Affiliation:
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Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain. jdgarcia@ugr.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials Colloids* Magnetics* Microscopy, Electron, Transmission Vehicles* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Colloids; 0/Vehicles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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