| Magnetic Resonance Imaging targeted biopsy in men with previously negative prostate biopsies. | |
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MedLine Citation:
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PMID: 22122555 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and purpose: To evaluate the efficacy of targeted prostatic biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathological features of tumors detected with targeted prostatic biopsy in men with negative previous prostatic biopsy results. Patients and Methods: We prospectively studied 87 patients with a persistently increasing level of serum prostate specific antigen (PSA), at least 1 previous set of negative 12 cores of prostatic biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using TRUS-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 and DQI images on their MRI. Results: Of total 87 cases, 82 patients (94.2%) had suspicious lesion(s) on their MRI. Of these 82 patients, 46 patients (56.0%) had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (p<0.05). Upon analysis by dividing all biopsy cores into the targeted cores and standard cores, PCA was found in 149/518 (28.8%) MRI-targeted cores and in 32/903 (3.6%) standard cores (p=0.012) Out of 43 patients who underwent radical prostatectomy, 37 patients (86.0%) were detected with PCA located at the anterior or apex portion of the prostate. For tumor characteristics according to tumor locations, there was no significant correlation between tumor location and Gleason scores or pathologic stage Conclusions: Our data suggest that a MRI-targeted prostatic biopsy following prostate MRI might be considered for the identification of cancer foci and the detection of PCA, for patients with a previous negative standard prostate biopsy despite persistent elevated PSA value. |
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Authors:
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Seung Hwan Lee; Mun Su Chung; Byung Ha Chung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
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Title: Journal of endourology / Endourological Society Volume: - ISSN: 1557-900X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807503 Medline TA: J Endourol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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712 Eonjuro Dogok dong, Gangnam gu, Seoul , Seoul, Korea, Republic of, 146-92; leeseh@yuhs.ac. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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