| Magnetic Resonance Imaging for Pancreatic Ductal Adenocarcinomas Induced by N-Nitrosobis (2-Oxopropyl) Amine in Syrian Golden Hamsters. | |
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MedLine Citation:
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PMID: 22249130 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS: A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated group (n = 80; with weekly subcutaneous injections of BOP [10 mg/kg body weight] for 7 consecutive weeks), a saline-treated group (n = 16), and an untreated group (n = 5). Hamsters underwent abdominal MRI on 1.5-T MR scanners with a dedicated animal radiofrequency coil. Findings of the tumor from the MRI were compared those from histology. RESULTS: Pancreata in the saline-treated and in the untreated groups were normal. In the BOP-treated group, there were 23 and 31 BOP-induced PDAs on macroscopy and microscopy, respectively. Of the PDAs detected on macroscopy, 65.2% were depicted on MRI. As early as 13 and 19 weeks after the first injection of BOP, PDAs in hamsters were found on histology and MRI, respectively. Moreover, the tumor volume on MRI was correlated with the tumor weights excised (r = 0.96, P = 0.000, n = 15). CONCLUSIONS: N-nitrosobis (2-oxopropyl) amine successfully induced PDAs in hamsters. Magnetic resonance imaging has the ability to detect healthy pancreas and PDAs in hamsters and has the potential to monitor the development of PDAs. |
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Authors:
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Qing Song Ma; Xiao Ming Zhang; Cheng Yi Shen; Nan Lin Zeng; Ze Shan Wu; Yu Pu; Chao Ying Wu; Li Sui Zhou; Zheng Wei Yang; Miao Zhang; Yang Shao |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Sichuan Key Laboratory of Medical Imaging, Departments of Radiology, †Physiopathology, and ‡Histology and Embryology, North Sichuan Medical College, Nanchong, Sichuan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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