Document Detail

Magnetic resonance-guided focused ultrasound surgery: Part 2: A review of current and future applications.
MedLine Citation:
PMID:  22791029     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a novel combination of technologies that is actively being realized as a noninvasive therapeutic tool for a myriad of conditions. These applications are reviewed with a focus on neurological use. A combined search of PubMed and MEDLINE was performed to identify the key events and current status of MRgFUS, with a focus on neurological applications. MRgFUS signifies a potentially ideal device for the treatment of neurological diseases. As it is nearly real time, it allows monitored provision of treatment location and energy deposition; is noninvasive, thereby limiting or eliminating disruption of normal tissue; provides focal delivery of therapeutic agents; enhances radiation delivery; and permits modulation of neural function. Multiple clinical applications are currently in clinical use and many more are under active preclinical investigation. The therapeutic potential of MRgFUS is expanding rapidly. Although clinically in its infancy, preclinical and early-phase I clinical trials in neurosurgery suggest a promising future for MRgFUS. Further investigation is necessary to define its true potential and impact.
Ricky Medel; Stephen J Monteith; W Jeffrey Elias; Matthew Eames; John Snell; Jason P Sheehan; Max Wintermark; Ferenc A Jolesz; Neal F Kassell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery     Volume:  71     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-02-27     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-63     Citation Subset:  IM    
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MeSH Terms
Brain Diseases / surgery*
Magnetic Resonance Imaging
PubMed / statistics & numerical data
Surgery, Computer-Assisted / methods*
Ultrasonic Therapy*
Grant Support
Comment In:
Neurosurgery. 2012 Oct;71(4):763   [PMID:  23162816 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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