| Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis. | |
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MedLine Citation:
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PMID: 19965849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in multiple sclerosis (MS), only a few MRI studies on cerebellar cortical pathology in MS are available. OBJECTIVE: To analyse cerebellar cortical volume (CCV) and leucocortical lesions (CL) in MS, and their impact on clinical disability. METHODS: The authors studied 125 patients divided into 38 Clinical Isolated Syndrome (CIS), 35 relapsing remitting multiple sclerosis (RRMS), 27 secondary progressive multiple sclerosis (SPMS) and 25 primary progressive multiple sclerosis, and 32 normal controls (NC). CCV and cerebellar CL number and volume were evaluated by means of Freesurfer software and Double Inversion Recovery, respectively. RESULTS: Compared with NC (mean 113.2 + or - 2.6 cm(3)), the CCV was significantly reduced in CIS (105.4 + or - 2.2 cm(3), p=0.018), RRMS (104.0 + or - 2.0 cm(3), p=0.012), SPMS (98.8 + or - 2.0 cm(3), p<0.001) and PPMS (100.6 + or - 2.2 cm(3), p<0.001), even after age, gender and mean cortical volume correction. CL were observed in all patient groups and were an independent predictor of CCV and cerebellar dysfunction. DISCUSSION: The authors confirm that the cerebellar cortex is severely and early affected by MS pathology. The monitoring of cerebellar cortical atrophy and CL may help to understand the mechanism underlying disability progression in MS. |
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Authors:
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Massimiliano Calabrese; Irene Mattisi; Francesca Rinaldi; Alice Favaretto; Matteo Atzori; Valentina Bernardi; Luigi Barachino; Chiara Romualdi; Luciano Rinaldi; Paola Perini; Paolo Gallo |
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Publication Detail:
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Type: Journal Article Date: 2009-12-03 |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 81 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: IM |
Affiliation:
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Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 3, 35128 Padua, Italy. calabresem@hotmail.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antineoplastic Agents / therapeutic use Atrophy / pathology Cerebellum / anatomy & histology, pathology* Disability Evaluation Female Humans Immunologic Factors / therapeutic use Interferon-beta / therapeutic use Magnetic Resonance Imaging* Male Middle Aged Mitoxantrone / therapeutic use Multiple Sclerosis, Relapsing-Remitting / drug therapy, pathology* Questionnaires Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Immunologic Factors; 145155-23-3/interferon beta-1b; 145258-61-3/interferon beta 1a; 65271-80-9/Mitoxantrone; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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