| Magnetic paclitaxel nanoparticles inhibit glioma growth and improve the survival of rats bearing glioma xenografts. | |
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MedLine Citation:
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PMID: 20651372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paclitaxel has fared poorly in clinical trials against brain glioma. We hypothesized that superparamagnetic nanocarriers may enhance its bioactivities by delivering it into the brain. MATERIALS AND METHODS: The magnetic paclitaxel nanoparticles (MPNPs) were fabricated and their cytotoxicity against glioma was tested both in vitro and in glioma-bearing rats. RESULTS: MPNPs exhibited superparamagnetism and produced an extended release of paclitaxel over 15 days in vitro. They were easily internalized into glioma cells and exerted remarkable toxicity, as free paclitaxel did. Furthermore, after intravenous injection of MPNPs to glioma-bearing rats and magnetic targeting with a 0.5 T magnet, drug content increased for 6- to 14-fold in implanted glioma and 4.6- to 12.1-fold in the normal brain compared to free paclitaxel. The survival of glioma-bearing rats was significantly prolonged after magnetic targeting therapy with MPNPs. CONCLUSION: MPNPs efficiently delivered paclitaxel into brain glioma by magnetic targeting and enhance its antitumor activity. They are promising for local chemotherapy for malignant glioma. |
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Authors:
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Ming Zhao; Chao Liang; Anmin Li; Jin Chang; Hanjie Wang; Runmin Yan; Jiajing Zhang; Junli Tai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2217-23 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, First Affiliated Hospital of PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048 PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / administration & dosage* Brain Neoplasms / drug therapy*, mortality, pathology Cell Line, Tumor Cerebral Cortex / metabolism Glioma / drug therapy*, mortality, pathology Humans Magnetics* Nanoparticles / administration & dosage* Paclitaxel / administration & dosage*, chemistry, metabolism Rats Rats, Sprague-Dawley Solubility Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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